Obatoclax Regulates the Proliferation and Fusion of Osteoclast Precursors through the Inhibition of ERK Activation by RANKL

Obatoclax, a pan-Bcl2 inhibitor, shows antitumor activities in various solid malignancies. Bcl2-deficient mice have shown the importance of Bcl2 in osteoclasts, as the bone mass of the mice was increased by the induced apoptosis of osteoclasts. Despite the importance of Bcl2, the effects of obatocla...

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Detalles Bibliográficos
Autores principales: Oh, Ju Hee, Lee, Jae Yoon, Park, Jin Hyeong, No, Jeong Hyeon, Lee, Na Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363729/
https://www.ncbi.nlm.nih.gov/pubmed/25666350
http://dx.doi.org/10.14348/molcells.2015.2340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363729/
https://www.ncbi.nlm.nih.gov/pubmed/25666350
http://dx.doi.org/10.14348/molcells.2015.2340

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