Synergetic Action of Domain II and IV Underlies Persistent Current Generation in Na(v)1.3 as revealed by a tarantula toxin

The persistent current (I(NaP)) through voltage-gated sodium channels enhances neuronal excitability by causing prolonged depolarization of membranes. Na(v)1.3 intrinsically generates a small I(NaP), although the mechanism underlying its generation remains unclear. In this study, the involvement of...

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Detalles Bibliográficos
Autores principales: Tang, Cheng, Zhou, Xi, Zhang, Yunxiao, xiao, Zhaohua, Hu, Zhaotun, Zhang, Changxin, Huang, Ying, Chen, Bo, Liu, Zhonghua, Liang, Songping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363837/
https://www.ncbi.nlm.nih.gov/pubmed/25784299
http://dx.doi.org/10.1038/srep09241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363837/
https://www.ncbi.nlm.nih.gov/pubmed/25784299
http://dx.doi.org/10.1038/srep09241

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