Ribosomes slide on lysine-encoding homopolymeric A stretches

Protein output from synonymous codons is thought to be equivalent if appropriate tRNAs are sufficiently abundant. Here we show that mRNAs encoding iterated lysine codons, AAA or AAG, differentially impact protein synthesis: insertion of iterated AAA codons into an ORF diminishes protein expression m...

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Detalles Bibliográficos
Autores principales: Koutmou, Kristin S, Schuller, Anthony P, Brunelle, Julie L, Radhakrishnan, Aditya, Djuranovic, Sergej, Green, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363877/
https://www.ncbi.nlm.nih.gov/pubmed/25695637
http://dx.doi.org/10.7554/eLife.05534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363877/
https://www.ncbi.nlm.nih.gov/pubmed/25695637
http://dx.doi.org/10.7554/eLife.05534

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