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Two-signal requirement for growth-promoting function of Yap in hepatocytes

The transcriptional coactivator Yes-associated protein (Yap) promotes proliferation and inhibits apoptosis, suggesting that Yap functions as an oncogene. Most oncogenes, however, require a combination of at least two signals to promote proliferation. In this study, we present evidence that Yap activ...

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Detalles Bibliográficos
Autores principales: Su, Tian, Bondar, Tanya, Zhou, Xu, Zhang, Cuiling, He, Hang, Medzhitov, Ruslan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363878/
https://www.ncbi.nlm.nih.gov/pubmed/25667983
http://dx.doi.org/10.7554/eLife.02948