Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation

Mechanistic understanding of nucleation dependent polymerization by α-synuclein (α-Syn) into toxic oligomers and amyloids is important for the drug development against Parkinson's disease. However the structural and morphological characterization during nucleation and subsequent fibrillation pr...

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Detalles Bibliográficos
Autores principales: Ghosh, Dhiman, Singh, Pradeep K., Sahay, Shruti, Jha, Narendra Nath, Jacob, Reeba S., Sen, Shamik, Kumar, Ashutosh, Riek, Roland, Maji, Samir K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363886/
https://www.ncbi.nlm.nih.gov/pubmed/25784353
http://dx.doi.org/10.1038/srep09228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363886/
https://www.ncbi.nlm.nih.gov/pubmed/25784353
http://dx.doi.org/10.1038/srep09228

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