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Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation
Mechanistic understanding of nucleation dependent polymerization by α-synuclein (α-Syn) into toxic oligomers and amyloids is important for the drug development against Parkinson's disease. However the structural and morphological characterization during nucleation and subsequent fibrillation pr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363886/ https://www.ncbi.nlm.nih.gov/pubmed/25784353 http://dx.doi.org/10.1038/srep09228 |