Cargando…

Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant

Background. In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemothe...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiménez-Hernández, Elva, Dueñas-González, María Teresa, Arellano-Galindo, José, Medrano-Ortíz-De-Zárate, María Elena, Bekker-Méndez, Vilma Carolina, Berges-García, Adolfina, Solís-Labastida, Karina, Sánchez-Jara, Berenice, Tiznado-García, Héctor Manuel, Jaimes-Reyes, Ethel Zulie, García-Jiménez, Xochiketzalli, Espinoza-Hernández, Laura, Núñez-Villegas, Nora Nancy, Franco-Ornelas, Sergio, Pérez-Casillas, Ruy Xavier, Martínez Villegas, Octavio, Palomares, Teresa Marin, Mejía-Aranguré, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363903/
https://www.ncbi.nlm.nih.gov/pubmed/25821830
http://dx.doi.org/10.1155/2015/940278
_version_ 1782361990796148736
author Jiménez-Hernández, Elva
Dueñas-González, María Teresa
Arellano-Galindo, José
Medrano-Ortíz-De-Zárate, María Elena
Bekker-Méndez, Vilma Carolina
Berges-García, Adolfina
Solís-Labastida, Karina
Sánchez-Jara, Berenice
Tiznado-García, Héctor Manuel
Jaimes-Reyes, Ethel Zulie
García-Jiménez, Xochiketzalli
Espinoza-Hernández, Laura
Núñez-Villegas, Nora Nancy
Franco-Ornelas, Sergio
Pérez-Casillas, Ruy Xavier
Martínez Villegas, Octavio
Palomares, Teresa Marin
Mejía-Aranguré, Juan Manuel
author_facet Jiménez-Hernández, Elva
Dueñas-González, María Teresa
Arellano-Galindo, José
Medrano-Ortíz-De-Zárate, María Elena
Bekker-Méndez, Vilma Carolina
Berges-García, Adolfina
Solís-Labastida, Karina
Sánchez-Jara, Berenice
Tiznado-García, Héctor Manuel
Jaimes-Reyes, Ethel Zulie
García-Jiménez, Xochiketzalli
Espinoza-Hernández, Laura
Núñez-Villegas, Nora Nancy
Franco-Ornelas, Sergio
Pérez-Casillas, Ruy Xavier
Martínez Villegas, Octavio
Palomares, Teresa Marin
Mejía-Aranguré, Juan Manuel
author_sort Jiménez-Hernández, Elva
collection PubMed
description Background. In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologous transplant, either underwent early intensified chemotherapy or did not undergo such treatment. Procedure. This was a cohort study with a historical control group, forty patients, less than 16 years old. Group A (20 patients), diagnosed in the period 2005–2007, was treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy: high doses of cytarabine and mitoxantrone. Group B (20 patients), diagnosed in the period 1999–2004, was treated as Group A, but without the early intensified chemotherapy. Results. Relapse-free survival for Group A was 90% whereas that for Group B it was 60% (P = 0.041). Overall survival for Group A (18, 90%) was higher than that for Group B (60%). Complete remission continued for two years of follow-up. Conclusions. Relapse-free survival for paediatric patients treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy was higher than that for those who did not receive early intensified chemotherapy.
format Online
Article
Text
id pubmed-4363903
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43639032015-03-29 Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant Jiménez-Hernández, Elva Dueñas-González, María Teresa Arellano-Galindo, José Medrano-Ortíz-De-Zárate, María Elena Bekker-Méndez, Vilma Carolina Berges-García, Adolfina Solís-Labastida, Karina Sánchez-Jara, Berenice Tiznado-García, Héctor Manuel Jaimes-Reyes, Ethel Zulie García-Jiménez, Xochiketzalli Espinoza-Hernández, Laura Núñez-Villegas, Nora Nancy Franco-Ornelas, Sergio Pérez-Casillas, Ruy Xavier Martínez Villegas, Octavio Palomares, Teresa Marin Mejía-Aranguré, Juan Manuel Biomed Res Int Research Article Background. In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologous transplant, either underwent early intensified chemotherapy or did not undergo such treatment. Procedure. This was a cohort study with a historical control group, forty patients, less than 16 years old. Group A (20 patients), diagnosed in the period 2005–2007, was treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy: high doses of cytarabine and mitoxantrone. Group B (20 patients), diagnosed in the period 1999–2004, was treated as Group A, but without the early intensified chemotherapy. Results. Relapse-free survival for Group A was 90% whereas that for Group B it was 60% (P = 0.041). Overall survival for Group A (18, 90%) was higher than that for Group B (60%). Complete remission continued for two years of follow-up. Conclusions. Relapse-free survival for paediatric patients treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy was higher than that for those who did not receive early intensified chemotherapy. Hindawi Publishing Corporation 2015 2015-03-02 /pmc/articles/PMC4363903/ /pubmed/25821830 http://dx.doi.org/10.1155/2015/940278 Text en Copyright © 2015 Elva Jiménez-Hernández et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jiménez-Hernández, Elva
Dueñas-González, María Teresa
Arellano-Galindo, José
Medrano-Ortíz-De-Zárate, María Elena
Bekker-Méndez, Vilma Carolina
Berges-García, Adolfina
Solís-Labastida, Karina
Sánchez-Jara, Berenice
Tiznado-García, Héctor Manuel
Jaimes-Reyes, Ethel Zulie
García-Jiménez, Xochiketzalli
Espinoza-Hernández, Laura
Núñez-Villegas, Nora Nancy
Franco-Ornelas, Sergio
Pérez-Casillas, Ruy Xavier
Martínez Villegas, Octavio
Palomares, Teresa Marin
Mejía-Aranguré, Juan Manuel
Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant
title Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant
title_full Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant
title_fullStr Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant
title_full_unstemmed Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant
title_short Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant
title_sort survival of mexican children with acute myeloid leukaemia who received early intensification chemotherapy and an autologous transplant
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363903/
https://www.ncbi.nlm.nih.gov/pubmed/25821830
http://dx.doi.org/10.1155/2015/940278
work_keys_str_mv AT jimenezhernandezelva survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT duenasgonzalezmariateresa survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT arellanogalindojose survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT medranoortizdezaratemariaelena survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT bekkermendezvilmacarolina survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT bergesgarciaadolfina survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT solislabastidakarina survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT sanchezjaraberenice survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT tiznadogarciahectormanuel survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT jaimesreyesethelzulie survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT garciajimenezxochiketzalli survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT espinozahernandezlaura survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT nunezvillegasnoranancy survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT francoornelassergio survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT perezcasillasruyxavier survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT martinezvillegasoctavio survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT palomaresteresamarin survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant
AT mejiaarangurejuanmanuel survivalofmexicanchildrenwithacutemyeloidleukaemiawhoreceivedearlyintensificationchemotherapyandanautologoustransplant