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Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant
Background. In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemothe...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363903/ https://www.ncbi.nlm.nih.gov/pubmed/25821830 http://dx.doi.org/10.1155/2015/940278 |
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author | Jiménez-Hernández, Elva Dueñas-González, María Teresa Arellano-Galindo, José Medrano-Ortíz-De-Zárate, María Elena Bekker-Méndez, Vilma Carolina Berges-García, Adolfina Solís-Labastida, Karina Sánchez-Jara, Berenice Tiznado-García, Héctor Manuel Jaimes-Reyes, Ethel Zulie García-Jiménez, Xochiketzalli Espinoza-Hernández, Laura Núñez-Villegas, Nora Nancy Franco-Ornelas, Sergio Pérez-Casillas, Ruy Xavier Martínez Villegas, Octavio Palomares, Teresa Marin Mejía-Aranguré, Juan Manuel |
author_facet | Jiménez-Hernández, Elva Dueñas-González, María Teresa Arellano-Galindo, José Medrano-Ortíz-De-Zárate, María Elena Bekker-Méndez, Vilma Carolina Berges-García, Adolfina Solís-Labastida, Karina Sánchez-Jara, Berenice Tiznado-García, Héctor Manuel Jaimes-Reyes, Ethel Zulie García-Jiménez, Xochiketzalli Espinoza-Hernández, Laura Núñez-Villegas, Nora Nancy Franco-Ornelas, Sergio Pérez-Casillas, Ruy Xavier Martínez Villegas, Octavio Palomares, Teresa Marin Mejía-Aranguré, Juan Manuel |
author_sort | Jiménez-Hernández, Elva |
collection | PubMed |
description | Background. In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologous transplant, either underwent early intensified chemotherapy or did not undergo such treatment. Procedure. This was a cohort study with a historical control group, forty patients, less than 16 years old. Group A (20 patients), diagnosed in the period 2005–2007, was treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy: high doses of cytarabine and mitoxantrone. Group B (20 patients), diagnosed in the period 1999–2004, was treated as Group A, but without the early intensified chemotherapy. Results. Relapse-free survival for Group A was 90% whereas that for Group B it was 60% (P = 0.041). Overall survival for Group A (18, 90%) was higher than that for Group B (60%). Complete remission continued for two years of follow-up. Conclusions. Relapse-free survival for paediatric patients treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy was higher than that for those who did not receive early intensified chemotherapy. |
format | Online Article Text |
id | pubmed-4363903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43639032015-03-29 Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant Jiménez-Hernández, Elva Dueñas-González, María Teresa Arellano-Galindo, José Medrano-Ortíz-De-Zárate, María Elena Bekker-Méndez, Vilma Carolina Berges-García, Adolfina Solís-Labastida, Karina Sánchez-Jara, Berenice Tiznado-García, Héctor Manuel Jaimes-Reyes, Ethel Zulie García-Jiménez, Xochiketzalli Espinoza-Hernández, Laura Núñez-Villegas, Nora Nancy Franco-Ornelas, Sergio Pérez-Casillas, Ruy Xavier Martínez Villegas, Octavio Palomares, Teresa Marin Mejía-Aranguré, Juan Manuel Biomed Res Int Research Article Background. In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologous transplant, either underwent early intensified chemotherapy or did not undergo such treatment. Procedure. This was a cohort study with a historical control group, forty patients, less than 16 years old. Group A (20 patients), diagnosed in the period 2005–2007, was treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy: high doses of cytarabine and mitoxantrone. Group B (20 patients), diagnosed in the period 1999–2004, was treated as Group A, but without the early intensified chemotherapy. Results. Relapse-free survival for Group A was 90% whereas that for Group B it was 60% (P = 0.041). Overall survival for Group A (18, 90%) was higher than that for Group B (60%). Complete remission continued for two years of follow-up. Conclusions. Relapse-free survival for paediatric patients treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy was higher than that for those who did not receive early intensified chemotherapy. Hindawi Publishing Corporation 2015 2015-03-02 /pmc/articles/PMC4363903/ /pubmed/25821830 http://dx.doi.org/10.1155/2015/940278 Text en Copyright © 2015 Elva Jiménez-Hernández et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jiménez-Hernández, Elva Dueñas-González, María Teresa Arellano-Galindo, José Medrano-Ortíz-De-Zárate, María Elena Bekker-Méndez, Vilma Carolina Berges-García, Adolfina Solís-Labastida, Karina Sánchez-Jara, Berenice Tiznado-García, Héctor Manuel Jaimes-Reyes, Ethel Zulie García-Jiménez, Xochiketzalli Espinoza-Hernández, Laura Núñez-Villegas, Nora Nancy Franco-Ornelas, Sergio Pérez-Casillas, Ruy Xavier Martínez Villegas, Octavio Palomares, Teresa Marin Mejía-Aranguré, Juan Manuel Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant |
title | Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant |
title_full | Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant |
title_fullStr | Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant |
title_full_unstemmed | Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant |
title_short | Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous Transplant |
title_sort | survival of mexican children with acute myeloid leukaemia who received early intensification chemotherapy and an autologous transplant |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363903/ https://www.ncbi.nlm.nih.gov/pubmed/25821830 http://dx.doi.org/10.1155/2015/940278 |
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