IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms

The transcription factor Tbet is critical for the differentiation of Th1 CD4 T cells and is associated with the induction of multiple autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate that Tbet suppresses IL-17A and Th17 differentiation both in vi...

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Autores principales: Yeh, Wen-I, McWilliams, Ian L., Harrington, Laurie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363997/
https://www.ncbi.nlm.nih.gov/pubmed/24369297
http://dx.doi.org/10.1016/j.jneuroim.2013.12.001
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author Yeh, Wen-I
McWilliams, Ian L.
Harrington, Laurie E.
author_facet Yeh, Wen-I
McWilliams, Ian L.
Harrington, Laurie E.
author_sort Yeh, Wen-I
collection PubMed
description The transcription factor Tbet is critical for the differentiation of Th1 CD4 T cells and is associated with the induction of multiple autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate that Tbet suppresses IL-17A and Th17 differentiation both in vitro and in vivo in a cell-intrinsic manner, and that in fact, Tbet is not necessary for EAE induction. Moreover, we find that IFNγ inhibits the production of IL-17A and IL-17F in a STAT1-dependent, Tbet-independent manner. These findings illustrate multiple mechanisms utilized by developing Th1 cells to silence the Th17 program.
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spelling pubmed-43639972015-03-18 IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms Yeh, Wen-I McWilliams, Ian L. Harrington, Laurie E. J Neuroimmunol Article The transcription factor Tbet is critical for the differentiation of Th1 CD4 T cells and is associated with the induction of multiple autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate that Tbet suppresses IL-17A and Th17 differentiation both in vitro and in vivo in a cell-intrinsic manner, and that in fact, Tbet is not necessary for EAE induction. Moreover, we find that IFNγ inhibits the production of IL-17A and IL-17F in a STAT1-dependent, Tbet-independent manner. These findings illustrate multiple mechanisms utilized by developing Th1 cells to silence the Th17 program. 2013-12-12 2014-02-15 /pmc/articles/PMC4363997/ /pubmed/24369297 http://dx.doi.org/10.1016/j.jneuroim.2013.12.001 Text en © 2013 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc/4.0/ This manuscript version is made available under the CC BY-NC-ND 4.0 license.
spellingShingle Article
Yeh, Wen-I
McWilliams, Ian L.
Harrington, Laurie E.
IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms
title IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms
title_full IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms
title_fullStr IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms
title_full_unstemmed IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms
title_short IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms
title_sort ifnγ inhibits th17 differentiation and function via tbet-dependent and tbet-independent mechanisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363997/
https://www.ncbi.nlm.nih.gov/pubmed/24369297
http://dx.doi.org/10.1016/j.jneuroim.2013.12.001
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