Inhibition of KIT-Glycosylation by 2-Deoxyglucose Abrogates KIT-Signaling and Combination with ABT-263 Synergistically Induces Apoptosis in Gastrointestinal Stromal Tumor

Positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) is frequently used for visualizing gastrointestinal stromal tumors (GIST), which are highly glucose-avid tumors. Dramatic metabolic responses following imatinib treatment indicate a high, KIT-dependent glucose turnover which has...

Descripción completa

Detalles Bibliográficos
Autores principales: Mühlenberg, Thomas, Grunewald, Susanne, Treckmann, Jürgen, Podleska, Lars, Schuler, Martin, Fletcher, Jonathan A., Bauer, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364009/
https://www.ncbi.nlm.nih.gov/pubmed/25781619
http://dx.doi.org/10.1371/journal.pone.0120531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364009/
https://www.ncbi.nlm.nih.gov/pubmed/25781619
http://dx.doi.org/10.1371/journal.pone.0120531

Ejemplares similares