Genetic Interaction between Tmprss2-ERG Gene Fusion and Nkx3.1-Loss Does Not Enhance Prostate Tumorigenesis in Mouse Models

Gene fusions involving ETS family transcription factors (mainly TMPRSS2-ERG and TMPRSS2-ETV1 fusions) have been found in ~50% of human prostate cancer cases. Although expression of TMPRSS2-ERG or TMPRSS2-ETV1 fusion alone is insufficient to initiate prostate tumorigenesis, they appear to sensitize p...

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Detalles Bibliográficos
Autores principales: Linn, Douglas E., Bronson, Roderick T., Li, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364018/
https://www.ncbi.nlm.nih.gov/pubmed/25780911
http://dx.doi.org/10.1371/journal.pone.0120628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364018/
https://www.ncbi.nlm.nih.gov/pubmed/25780911
http://dx.doi.org/10.1371/journal.pone.0120628

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