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Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain
BACKGROUND: Cav3.2 channels facilitate nociceptive transmission and are upregulated in DRG neurons in response to nerve injury or peripheral inflammation. We reported that this enhancement of Cav3.2 currents in afferent neurons is mediated by deubiquitination of the channels by the deubiquitinase US...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364099/ https://www.ncbi.nlm.nih.gov/pubmed/25889575 http://dx.doi.org/10.1186/s12990-015-0011-8 |