Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain

BACKGROUND: Cav3.2 channels facilitate nociceptive transmission and are upregulated in DRG neurons in response to nerve injury or peripheral inflammation. We reported that this enhancement of Cav3.2 currents in afferent neurons is mediated by deubiquitination of the channels by the deubiquitinase US...

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Detalles Bibliográficos
Autores principales: Gadotti, Vinicius M, Caballero, Agustin Garcia, Berger, N Daniel, Gladding, Clare M, Chen, Lina, Pfeifer, Tom A, Zamponi, Gerald W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364099/
https://www.ncbi.nlm.nih.gov/pubmed/25889575
http://dx.doi.org/10.1186/s12990-015-0011-8

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