Elucidating organ-specific metabolic toxicity chemistry from electrochemiluminescent enzyme/DNA arrays and bioreactor bead-LC-MS/MS

Human toxic responses are very often related to metabolism. Liver metabolism is traditionally studied, but other organs also convert chemicals and drugs to reactive metabolites leading to toxicity. When DNA damage is found, the effects are termed genotoxic. Here we describe a comprehensive new appro...

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Detalles Bibliográficos
Autores principales: Wasalathanthri, Dhanuka P., Li, Dandan, Song, Donghui, Zheng, Zhifang, Choudhary, Dharamainder, Jansson, Ingela, Lu, Xiuling, Schenkman, John B., Rusling, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364445/
https://www.ncbi.nlm.nih.gov/pubmed/25798217
http://dx.doi.org/10.1039/c4sc03401e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364445/
https://www.ncbi.nlm.nih.gov/pubmed/25798217
http://dx.doi.org/10.1039/c4sc03401e

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