In Vivo Therapeutic Protection against Influenza A (H1N1) Oseltamivir-Sensitive and Resistant Viruses by the Iminosugar UV-4

Our lead iminosugar analog called UV-4 or N-(9-methoxynonyl)-1-deoxynojirimycin inhibits activity of endoplasmic reticulum (ER) α-glucosidases I and II and is a potent, host-targeted antiviral candidate. The mechanism of action for the antiviral activity of iminosugars is proposed to be inhibition o...

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Detalles Bibliográficos
Autores principales: Stavale, Eric J., Vu, Hong, Sampath, Aruna, Ramstedt, Urban, Warfield, Kelly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364785/
https://www.ncbi.nlm.nih.gov/pubmed/25786028
http://dx.doi.org/10.1371/journal.pone.0121662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364785/
https://www.ncbi.nlm.nih.gov/pubmed/25786028
http://dx.doi.org/10.1371/journal.pone.0121662

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