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The cerebral cavernous malformation 3 gene is necessary for senescence induction

Mutations in cerebral cavernous malformation 3 gene are known to result in development of vascular malformations and have recently been proposed to also give rise to meningiomas. We report in this study that lack of CCM3 unexpectedly impairs the senescence response of cells, and this is related to t...

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Detalles Bibliográficos
Autores principales: Guerrero, Ana, Iglesias, Cristina, Raguz, Selina, Floridia, Ebel, Gil, Jesús, Pombo, Celia M, Zalvide, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364839/
https://www.ncbi.nlm.nih.gov/pubmed/25655101
http://dx.doi.org/10.1111/acel.12316