Dissociation of SHP-1 from Spinophilin during Platelet Activation Exposes an Inhibitory Binding Site for Protein Phosphatase-1 (PP1)

We have recently shown that a critical regulatory node in the platelet signaling network lies immediately downstream of platelet receptors for thrombin and TxA(2). This node is comprised of a scaffold protein (spinophilin, SPL), a protein tyrosine phosphatase (SHP-1), and either of the two members o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Peisong, Foote, Darci C., Sinnamon, Andrew J., Brass, Lawrence F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364895/
https://www.ncbi.nlm.nih.gov/pubmed/25785436
http://dx.doi.org/10.1371/journal.pone.0119496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364895/
https://www.ncbi.nlm.nih.gov/pubmed/25785436
http://dx.doi.org/10.1371/journal.pone.0119496

Ejemplares similares