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Human β-Defensin 4 with Non-Native Disulfide Bridges Exhibit Antimicrobial Activity
Human defensins play multiple roles in innate immunity including direct antimicrobial killing and immunomodulatory activity. They have three disulfide bridges which contribute to the stability of three anti-parallel β-strands. The exact role of disulfide bridges and canonical β-structure in the anti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364940/ https://www.ncbi.nlm.nih.gov/pubmed/25785690 http://dx.doi.org/10.1371/journal.pone.0119525 |