Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance

Pattern recognition receptors link metabolite and bacteria-derived inflammation to insulin resistance during obesity. We demonstrate that NOD2 detection of bacterial cell wall peptidoglycan (PGN) regulates metabolic inflammation and insulin sensitivity. An obesity-promoting high-fat diet (HFD) incre...

Descripción completa

Detalles Bibliográficos
Autores principales: Denou, Emmanuel, Lolmède, Karine, Garidou, Lucile, Pomie, Celine, Chabo, Chantal, Lau, Trevor C, Fullerton, Morgan D, Nigro, Giulia, Zakaroff-Girard, Alexia, Luche, Elodie, Garret, Céline, Serino, Matteo, Amar, Jacques, Courtney, Michael, Cavallari, Joseph F, Henriksbo, Brandyn D, Barra, Nicole G, Foley, Kevin P, McPhee, Joseph B, Duggan, Brittany M, O'Neill, Hayley M, Lee, Amanda J, Sansonetti, Philippe, Ashkar, Ali A, Khan, Waliul I, Surette, Michael G, Bouloumié, Anne, Steinberg, Gregory R, Burcelin, Rémy, Schertzer, Jonathan D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364944/
https://www.ncbi.nlm.nih.gov/pubmed/25666722
http://dx.doi.org/10.15252/emmm.201404169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364944/
https://www.ncbi.nlm.nih.gov/pubmed/25666722
http://dx.doi.org/10.15252/emmm.201404169

Ejemplares similares