Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

The cellular prion protein (PrP(C)) comprises a natively unstructured N-terminal domain, including a metal-binding octarepeat region (OR) and a linker, followed by a C-terminal domain that misfolds to form PrP(S)(c) in Creutzfeldt-Jakob disease. PrP(C) β-endoproteolysis to the C2 fragment allows PrP...

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Detalles Bibliográficos
Autores principales: Lau, Agnes, McDonald, Alex, Daude, Nathalie, Mays, Charles E, Walter, Eric D, Aglietti, Robin, Mercer, Robert CC, Wohlgemuth, Serene, van der Merwe, Jacques, Yang, Jing, Gapeshina, Hristina, Kim, Chae, Grams, Jennifer, Shi, Beipei, Wille, Holger, Balachandran, Aru, Schmitt-Ulms, Gerold, Safar, Jiri G, Millhauser, Glenn L, Westaway, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364950/
https://www.ncbi.nlm.nih.gov/pubmed/25661904
http://dx.doi.org/10.15252/emmm.201404588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364950/
https://www.ncbi.nlm.nih.gov/pubmed/25661904
http://dx.doi.org/10.15252/emmm.201404588

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