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Methotrexate as combination partner of TNF inhibitors and tocilizumab. What is reasonable from an immunological viewpoint?

The goal of therapy of rheumatoid arthritis is to achieve a remission or at least low disease activity. TNF inhibitors induce high remission rates only in combination with methotrexate, whereas the efficacy of tocilizumab is optimal even as a monotherapy. In this article, the differing dependence of...

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Detalles Bibliográficos
Autor principal: Witte, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365184/
https://www.ncbi.nlm.nih.gov/pubmed/25604317
http://dx.doi.org/10.1007/s10067-015-2861-x