A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females

Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females (P=6.89 × 10(−9)) but not males (P=0.71). This a...

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Detalles Bibliográficos
Autores principales: Sharma, Swarkar, Londono, Douglas, Eckalbar, Walter L., Gao, Xiaochong, Zhang, Dongping, Mauldin, Kristen, Kou, Ikuyo, Takahashi, Atsushi, Matsumoto, Morio, Kamiya, Nobuhiro, Murphy, Karl K., Cornelia, Reuel, Herring, John A., Burns, Dennis, Ahituv, Nadav, Ikegawa, Shiro, Gordon, Derek, Wise, Carol A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365504/
https://www.ncbi.nlm.nih.gov/pubmed/25784220
http://dx.doi.org/10.1038/ncomms7452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365504/
https://www.ncbi.nlm.nih.gov/pubmed/25784220
http://dx.doi.org/10.1038/ncomms7452

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