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A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females
Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females (P=6.89 × 10(−9)) but not males (P=0.71). This a...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365504/ https://www.ncbi.nlm.nih.gov/pubmed/25784220 http://dx.doi.org/10.1038/ncomms7452 |