Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

Shank3 is a postsynaptic scaffolding protein implicated in synapse development and autism spectrum disorders. The Shank3 gene is known to produce diverse splice variants whose functions have not been fully explored. In the present study, we generated mice lacking Shank3 exon 9 (Shank3(Δ9) mice), and...

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Detalles Bibliográficos
Autores principales: Lee, Jiseok, Chung, Changuk, Ha, Seungmin, Lee, Dongmin, Kim, Do-Young, Kim, Hyun, Kim, Eunjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365696/
https://www.ncbi.nlm.nih.gov/pubmed/25852484
http://dx.doi.org/10.3389/fncel.2015.00094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365696/
https://www.ncbi.nlm.nih.gov/pubmed/25852484
http://dx.doi.org/10.3389/fncel.2015.00094

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