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Differential effects of two MRI contrast agents on the integrity and distribution of rAAV2 and rAAV5 in the rat striatum

Intraoperative magnetic resonance imaging (MRI) has been proposed as a method to optimize intracerebral targeting and for tracking infusate distribution in gene therapy trials for nervous system disorders. We thus investigated possible effects of two MRI contrast agents, gadoteridol (Gd) and galbumi...

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Detalles Bibliográficos
Autores principales: Osting, Sue, Bennett, Antonette, Power, Shelby, Wackett, Jordan, Hurley, Samuel A, Alexander, Andrew L, Agbandje-Mckena, Mavis, Burger, Corinna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365861/
https://www.ncbi.nlm.nih.gov/pubmed/26015943
http://dx.doi.org/10.1038/mtm.2013.4