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Kinetic Evaluation of Photosensitivity in Bi-Stable Variants of Chimeric Channelrhodopsins

Channelrhodopsin-1 and 2 (ChR1 and ChR2) form cation channels that are gated by light through an unknown mechanism. We tested the DC-gate hypothesis that C167 and D195 are involved in the stabilization of the cation-permeable state of ChRWR/C1C2 which consists of TM1-5 of ChR1 and TM6-7 of ChR2 and...

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Detalles Bibliográficos
Autores principales: Hososhima, Shoko, Sakai, Seiichiro, Ishizuka, Toru, Yawo, Hiromu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366085/
https://www.ncbi.nlm.nih.gov/pubmed/25789474
http://dx.doi.org/10.1371/journal.pone.0119558