Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics

The epidermal growth factor receptor (EGFR) is overexpressed in multiple carcinomas and is the focus of a variety of targeted therapies. Here we report the design of peptide-based compounds that mimic the EGFR dimerization arm and inhibit allosteric activation of EGFR. These peptides are modified to...

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Detalles Bibliográficos
Autores principales: Hanold, Laura E., Oruganty, Krishnadev, Ton, Norman T., Beedle, Aaron M., Kannan, Natarajan, Kennedy, Eileen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366150/
https://www.ncbi.nlm.nih.gov/pubmed/25790232
http://dx.doi.org/10.1371/journal.pone.0118796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366150/
https://www.ncbi.nlm.nih.gov/pubmed/25790232
http://dx.doi.org/10.1371/journal.pone.0118796

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