Cargando…
Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics
The epidermal growth factor receptor (EGFR) is overexpressed in multiple carcinomas and is the focus of a variety of targeted therapies. Here we report the design of peptide-based compounds that mimic the EGFR dimerization arm and inhibit allosteric activation of EGFR. These peptides are modified to...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366150/ https://www.ncbi.nlm.nih.gov/pubmed/25790232 http://dx.doi.org/10.1371/journal.pone.0118796 |