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Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein
Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson’s disease (PD). The formation of α-syn aggregates results from aberrant accumulation of misfolded α-syn and insufficient or impaired activity of the two main intracell...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366176/ https://www.ncbi.nlm.nih.gov/pubmed/25790376 http://dx.doi.org/10.1371/journal.pone.0120819 |