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Single Amino Acid Change in STING Leads to Constitutive Active Signaling
The production of cytokines by the immune system in response to cytosolic DNA plays an important role in host defense, autoimmune disease, and cancer immunogenicity. Recently a cytosolic DNA signaling pathway that is dependent on the endoplasmic reticulum adaptor and cyclic dinucleotide sensor prote...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366210/ https://www.ncbi.nlm.nih.gov/pubmed/25790474 http://dx.doi.org/10.1371/journal.pone.0120090 |