Cargando…

Single Amino Acid Change in STING Leads to Constitutive Active Signaling

The production of cytokines by the immune system in response to cytosolic DNA plays an important role in host defense, autoimmune disease, and cancer immunogenicity. Recently a cytosolic DNA signaling pathway that is dependent on the endoplasmic reticulum adaptor and cyclic dinucleotide sensor prote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Eric D., Wang, Cun-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366210/ https://www.ncbi.nlm.nih.gov/pubmed/25790474 http://dx.doi.org/10.1371/journal.pone.0120090

Ejemplares similares

Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice
por: Szego, Eva M, et al.
Publicado: (2022)

Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity
por: Liu, Wei, et al.
Publicado: (2022)

Effects of a Honeybee Sting on the Serum Free Amino Acid Profile in Humans
por: Matysiak, Jan, et al.
Publicado: (2014)

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling
por: Lepelley, Alice, et al.
Publicado: (2020)

STEEP mediates STING ER exit and activation of signaling
por: Zhang, Bao-cun, et al.
Publicado: (2020)

STING Signaling and Skin Cancers
por: Sato, Sayaka, et al.
Publicado: (2021)

Dramatic activation of an antibody by a single amino acid change in framework
por: Liang, Wei-Ching, et al.
Publicado: (2021)

Activation of the cGAS–STING signaling pathway in adenomyosis patients
por: Lin, Yun, et al.
Publicado: (2021)

Mannosylated Linear and Cyclic Single Amino Acid Mutant Peptides Using a Small 10 Amino Acid Linker Constitute Promising Candidates Against Multiple Sclerosis
por: Day, Stephanie, et al.
Publicado: (2015)

Expression of a constitutively active human STING mutant in hematopoietic cells produces an Ifnar1-dependent vasculopathy in mice
por: Martin, Gary R, et al.
Publicado: (2019)

Carbolic Acid and Scorpion Stings
por: Dhandhukia, C. G.
Publicado: (1917)

STING Signaling and Sterile Inflammation
por: Couillin, Isabelle, et al.
Publicado: (2021)

STING activation in cancer immunotherapy
por: Su, Ting, et al.
Publicado: (2019)

WASP stings into matrix to lead immune cell migration
por: Rottner, Klemens, et al.
Publicado: (2022)

Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic‐Like Behaviors
por: Zhang, Dongming, et al.
Publicado: (2020)

A Single Amino Acid Substitution in MIL1 Leads to Activation of Programmed Cell Death and Defense Responses in Rice
por: Yan, Bowen, et al.
Publicado: (2022)

Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans
por: Chung, Sun-Ku, et al.
Publicado: (2014)

Constitutive Expression of AID Leads to Tumorigenesis
por: Okazaki, Il-mi, et al.
Publicado: (2003)

mRNA-encoded, constitutively active STING(V155M) is a potent genetic adjuvant of antigen-specific CD8(+) T cell response
por: Tse, Sze-Wah, et al.
Publicado: (2021)

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling
por: Nandakumar, Ramya, et al.
Publicado: (2019)

CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer
por: Cornelison, Robert, et al.
Publicado: (2021)

Minimal Change Disease Is Associated with Mitochondrial Injury and STING Pathway Activation
por: Yu, Byung Chul, et al.
Publicado: (2022)

Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy
por: Luo, Kewang, et al.
Publicado: (2022)

Goose STING mediates IFN signaling activation against RNA viruses
por: Fu, Feiyu, et al.
Publicado: (2022)

Synergistic Effects of Azithromycin and STING Agonist Promote IFN-I Production by Enhancing the Activation of STING-TBK1 Signaling
por: Petcharat, Kanoktip, et al.
Publicado: (2023)

STING Signaling in Cancer Cells: Important or Not?
por: Sokolowska, Olga, et al.
Publicado: (2017)

Involvement of the STING signaling in COVID-19
por: Xiao, Ruoxuan, et al.
Publicado: (2022)

Deficiency in coatomer complex I causes aberrant activation of STING signalling
por: Steiner, Annemarie, et al.
Publicado: (2022)

Amino Acid Sequence in Constitutionally Isomeric Tetrapeptide Amphiphiles Dictates Architecture of One-Dimensional Nanostructures
por: Cui, Honggang, et al.
Publicado: (2014)

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway
por: Krivega, Maria, et al.
Publicado: (2021)

Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
por: Heath, Blake R., et al.
Publicado: (2023)

Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G(s) signaling
por: Nie, Yingying, et al.
Publicado: (2023)

Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis
por: Xia, Nengwen, et al.
Publicado: (2022)

Function and regulation of cGAS-STING signaling in infectious diseases
por: Du, Yang, et al.
Publicado: (2023)

Interruption of post-Golgi STING trafficking activates tonic interferon signaling
por: Tu, Xintao, et al.
Publicado: (2022)

A Single Amino Acid Residue Constitutes the Third Dimerization Domain Essential for the Assembly and Function of the Tetrameric Polycystin-2 (TRPP2) Channel
por: Feng, Shuang, et al.
Publicado: (2011)

Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast
por: Liu, Qingbin, et al.
Publicado: (2015)

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth
por: Wilson, Sarah M., et al.
Publicado: (2014)

Predict impact of single amino acid change upon protein structure
por: Schaefer, Christian, et al.
Publicado: (2012)

Phylogenetic inference of changes in amino acid propensities with single-position resolution
por: Klink, Galya V., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_a6ndn2g31ke4bpj0543g9b40pg