The Structure of SpnF, a Standalone Enzyme that Catalyzes [4+2] Cycloaddition

In the biosynthetic pathway of the spinosyn insecticides, the tailoring enzyme SpnF performs a [4+2]-cycloaddition on a 22-membered macrolactone to forge an embedded cyclohexene ring. To learn more about this reaction, which could potentially proceed through a Diels-Alder mechanism, the 1.50 Å-resol...

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Detalles Bibliográficos
Autores principales: Fage, Christopher D., Isiorho, Eta A., Liu, Yungnan, Wagner, Drew T., Liu, Hung-wen, Keatinge-Clay, Adrian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366278/
https://www.ncbi.nlm.nih.gov/pubmed/25730549
http://dx.doi.org/10.1038/nchembio.1768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366278/
https://www.ncbi.nlm.nih.gov/pubmed/25730549
http://dx.doi.org/10.1038/nchembio.1768

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