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The Structure of SpnF, a Standalone Enzyme that Catalyzes [4+2] Cycloaddition
In the biosynthetic pathway of the spinosyn insecticides, the tailoring enzyme SpnF performs a [4+2]-cycloaddition on a 22-membered macrolactone to forge an embedded cyclohexene ring. To learn more about this reaction, which could potentially proceed through a Diels-Alder mechanism, the 1.50 Å-resol...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366278/ https://www.ncbi.nlm.nih.gov/pubmed/25730549 http://dx.doi.org/10.1038/nchembio.1768 |