Topically applied Hsp90 inhibitor 17AAG inhibits ultraviolet radiation-induced cutaneous squamous cell carcinomas

We present here that Heat shock protein 90 (Hsp90) inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17AAG), when topically applied to mouse skin, inhibits ultraviolet radiation (UVR)-induced development of cutaneous squamous cell carcinoma (SCC). In these experiments, DMSO:acetone (1:40 v/v) solu...

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Detalles Bibliográficos
Autores principales: Singh, Anupama, Singh, Ashok, Sand, Jordan M., Bauer, Samuel J., Hafeez, Bilal Bin, Meske, Louise, Verma, Ajit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366283/
https://www.ncbi.nlm.nih.gov/pubmed/25337691
http://dx.doi.org/10.1038/jid.2014.460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366283/
https://www.ncbi.nlm.nih.gov/pubmed/25337691
http://dx.doi.org/10.1038/jid.2014.460

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