Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated

The involvement of the ubiquitin-proteasome system (UPS) in the course of various age-associated neurodegenerative diseases is well established. The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson’s disease (PD) variant and was found to interact with ATXN2, a prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Halbach, Melanie Vanessa, Stehning, Tanja, Damrath, Ewa, Jendrach, Marina, Şen, Nesli Ece, Başak, A. Nazlı, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366354/
https://www.ncbi.nlm.nih.gov/pubmed/25790475
http://dx.doi.org/10.1371/journal.pone.0121089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366354/
https://www.ncbi.nlm.nih.gov/pubmed/25790475
http://dx.doi.org/10.1371/journal.pone.0121089

Ejemplares similares