Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protei...

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Detalles Bibliográficos
Autores principales: Madhusudhan, Thati, Wang, Hongjie, Dong, Wei, Ghosh, Sanchita, Bock, Fabian, Thangapandi, Veera Raghavan, Ranjan, Satish, Wolter, Juliane, Kohli, Shrey, Shahzad, Khurrum, Heidel, Florian, Krueger, Martin, Schwenger, Vedat, Moeller, Marcus J., Kalinski, Thomas, Reiser, Jochen, Chavakis, Triantafyllos, Isermann, Berend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366504/
https://www.ncbi.nlm.nih.gov/pubmed/25754093
http://dx.doi.org/10.1038/ncomms7496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366504/
https://www.ncbi.nlm.nih.gov/pubmed/25754093
http://dx.doi.org/10.1038/ncomms7496

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