MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

Tight control of T follicular helper (Tfh) cells is required for optimal maturation of the germinal centre (GC) response. The molecular mechanisms controlling Tfh-cell differentiation remain incompletely understood. Here we show that microRNA-146a (miR-146a) is highly expressed in Tfh cells and peak...

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Detalles Bibliográficos
Autores principales: Pratama, Alvin, Srivastava, Monika, Williams, Naomi J., Papa, Ilenia, Lee, Sau K., Dinh, Xuyen T., Hutloff, Andreas, Jordan, Margaret A., Zhao, Jimmy L., Casellas, Rafael, Athanasopoulos, Vicki, Vinuesa, Carola G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366510/
https://www.ncbi.nlm.nih.gov/pubmed/25743066
http://dx.doi.org/10.1038/ncomms7436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366510/
https://www.ncbi.nlm.nih.gov/pubmed/25743066
http://dx.doi.org/10.1038/ncomms7436

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