Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs

An established means of improving the pharmacokinetics properties of oligoribonucleotides (ORNs) is to exchange their phosphodiester linkages for phosphorothioates (PSs). However, this strategy has not been pursued for small interfering RNAs (siRNAs), possibly because of sporadic reports that PS siR...

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Detalles Bibliográficos
Autores principales: Jahns, Hartmut, Roos, Martina, Imig, Jochen, Baumann, Fabienne, Wang, Yuluan, Gilmour, Ryan, Hall, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366519/
https://www.ncbi.nlm.nih.gov/pubmed/25744034
http://dx.doi.org/10.1038/ncomms7317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366519/
https://www.ncbi.nlm.nih.gov/pubmed/25744034
http://dx.doi.org/10.1038/ncomms7317

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