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Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease
The brains of Alzheimer’s disease (AD) patients are characterized by deposits of Abeta peptides and by accompanying chronic inflammation. Here, we provide evidence that the enzyme isoglutaminyl cyclase (isoQC) is a novel factor contributing to both aspects of AD pathology. Two putative substrates of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366547/ https://www.ncbi.nlm.nih.gov/pubmed/25666182 http://dx.doi.org/10.1007/s00401-015-1395-2 |