Cargando…
Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease
The brains of Alzheimer’s disease (AD) patients are characterized by deposits of Abeta peptides and by accompanying chronic inflammation. Here, we provide evidence that the enzyme isoglutaminyl cyclase (isoQC) is a novel factor contributing to both aspects of AD pathology. Two putative substrates of...
Autores principales: | Hartlage-Rübsamen, Maike, Waniek, Alexander, Meißner, Juliane, Morawski, Markus, Schilling, Stephan, Jäger, Carsten, Kleinschmidt, Martin, Cynis, Holger, Kehlen, Astrid, Arendt, Thomas, Demuth, Hans-Ulrich, Roßner, Steffen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366547/ https://www.ncbi.nlm.nih.gov/pubmed/25666182 http://dx.doi.org/10.1007/s00401-015-1395-2 |
Ejemplares similares
-
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2011) -
Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease
por: Morawski, Markus, et al.
Publicado: (2010) -
Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer’s disease-like pathology
por: Gnoth, Kathrin, et al.
Publicado: (2020) -
Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2018) -
N-terminal pyroglutamate formation in CX3CL1 is essential for its
full biologic activity
por: Kehlen, Astrid, et al.
Publicado: (2017)