MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer

The serine-threonine kinase CK2 exhibits genomic alterations and aberrant overexpression in human head and neck squamous cell carcinomas (HNSCC). Here, we investigated the effects of CK2 inhibitor CX-4945 in human HNSCC cell lines and xenograft models. The IC(50's )of CX-4945 for 9 UM-SCC cell...

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Detalles Bibliográficos
Autores principales: Bian, Yansong, Han, Jiawei, Kannabiran, Vishnu, Mohan, Suresh, Cheng, Hui, Friedman, Jay, Zhang, Luo, VanWaes, Carter, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366640/
https://www.ncbi.nlm.nih.gov/pubmed/25798061
http://dx.doi.org/10.7150/ijbs.10745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366640/
https://www.ncbi.nlm.nih.gov/pubmed/25798061
http://dx.doi.org/10.7150/ijbs.10745

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