C(6)-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation

Nanoliposomal formulation of C(6)-ceramide, a proapoptotic sphingolipid metabolite, presents an effective way to treat malignant tumor. Here, we provide evidence that acute treatment (30 min) of melanoma and breast cancer cells with nanoliposomal C(6)-ceramide (NaL-C(6)) may suppress cell migration...

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Detalles Bibliográficos
Autores principales: Zhang, Pu, Fu, Changliang, Hu, Yijuan, Dong, Cheng, Song, Yang, Song, Erqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366857/
https://www.ncbi.nlm.nih.gov/pubmed/25792190
http://dx.doi.org/10.1038/srep09275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366857/
https://www.ncbi.nlm.nih.gov/pubmed/25792190
http://dx.doi.org/10.1038/srep09275

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