Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer

BACKGROUND: Activation of the PI3K/mTOR and Hedgehog (Hh) signalling pathways occurs frequently in biliary tract cancer (BTC). Crosstalk between these pathways occurs in other gastrointestinal cancers. The respective signalling inhibitors rapamycin and vismodegib may inhibit BTC synergistically and...

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Detalles Bibliográficos
Autores principales: Zuo, M, Rashid, A, Churi, C, Vauthey, J-N, Chang, P, Li, Y, Hung, M-C, Li, D, Javle, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366884/
https://www.ncbi.nlm.nih.gov/pubmed/25742482
http://dx.doi.org/10.1038/bjc.2014.625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366884/
https://www.ncbi.nlm.nih.gov/pubmed/25742482
http://dx.doi.org/10.1038/bjc.2014.625

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