Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients

BACKGROUND: PPM1D (WIP1) negatively regulates by dephosphorylation many proteins including p53 tumour suppressor. The truncating mutations (nonsense and frameshift) in exon 6 of PPM1D were found recently in blood cells of patients with breast, ovarian or colorectal cancer. These mutants code for gai...

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Detalles Bibliográficos
Autores principales: Zajkowicz, A, Butkiewicz, D, Drosik, A, Giglok, M, Suwiński, R, Rusin, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366904/
https://www.ncbi.nlm.nih.gov/pubmed/25742468
http://dx.doi.org/10.1038/bjc.2015.79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366904/
https://www.ncbi.nlm.nih.gov/pubmed/25742468
http://dx.doi.org/10.1038/bjc.2015.79

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