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Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients
BACKGROUND: PPM1D (WIP1) negatively regulates by dephosphorylation many proteins including p53 tumour suppressor. The truncating mutations (nonsense and frameshift) in exon 6 of PPM1D were found recently in blood cells of patients with breast, ovarian or colorectal cancer. These mutants code for gai...
Autores principales: | Zajkowicz, A, Butkiewicz, D, Drosik, A, Giglok, M, Suwiński, R, Rusin, M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366904/ https://www.ncbi.nlm.nih.gov/pubmed/25742468 http://dx.doi.org/10.1038/bjc.2015.79 |
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