A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation

Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the different species. For discovery of a diverse panel of unique therapeutic antibody candidates, chickens therefore represent an attractive host for human-derived...

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Detalles Bibliográficos
Autores principales: Leighton, Philip A., Schusser, Benjamin, Yi, Henry, Glanville, Jacob, Harriman, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367436/
https://www.ncbi.nlm.nih.gov/pubmed/25852694
http://dx.doi.org/10.3389/fimmu.2015.00126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367436/
https://www.ncbi.nlm.nih.gov/pubmed/25852694
http://dx.doi.org/10.3389/fimmu.2015.00126

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