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Neurotoxic effects of AZT on developing and adult neurogenesis

Azidothymidine (AZT) is a synthetic, chain-terminating nucleoside analog used to treat HIV-1 infection. While AZT is not actively transported across the blood brain barrier, it does accumulate at high levels in cerebrospinal fluid, and subsequently diffuses into the overlying parenchyma. Due to the...

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Detalles Bibliográficos
Autores principales: Demir, Meryem, Laywell, Eric D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367529/
https://www.ncbi.nlm.nih.gov/pubmed/25852464
http://dx.doi.org/10.3389/fnins.2015.00093