Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression

INTRODUCTION: The emergence of hormone therapy resistance, despite continued expression of the estrogen receptor (ER), is a major challenge to curing breast cancer. Recent clinical studies suggest that epigenetic modulation by histone deacetylase (HDAC) inhibitors reverses hormone therapy resistance...

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Detalles Bibliográficos
Autores principales: Raha, Paromita, Thomas, Scott, Thurn, K Ted, Park, Jeenah, Munster, Pamela N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367983/
https://www.ncbi.nlm.nih.gov/pubmed/25848915
http://dx.doi.org/10.1186/s13058-015-0533-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367983/
https://www.ncbi.nlm.nih.gov/pubmed/25848915
http://dx.doi.org/10.1186/s13058-015-0533-z

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