Folic Acid Supplementation during Pregnancy Induces Sex-Specific Changes in Methylation and Expression of Placental 11β-Hydroxysteroid Dehydrogenase 2 in Rats

In the placenta, 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) limits fetal glucocorticoid exposure and its inhibition has been associated to low birth weight. Its expression, encoded by the HSD11B2 gene is regulated by DNA methylation. We hypothesized that maternal diets supplemented with foli...

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Detalles Bibliográficos
Autores principales: Penailillo, Reyna, Guajardo, Angelica, Llanos, Miguel, Hirsch, Sandra, Ronco, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368185/
https://www.ncbi.nlm.nih.gov/pubmed/25793274
http://dx.doi.org/10.1371/journal.pone.0121098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368185/
https://www.ncbi.nlm.nih.gov/pubmed/25793274
http://dx.doi.org/10.1371/journal.pone.0121098

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