Interleukin-7 co-ordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection

pre-T cell receptor (TCR) and Notch signaling induce transient self-renewal or “β-selection” of TCRβ(+) CD4 CD8 double-negative-3 (DN3) and DN4 progenitors that differentiate into CD4 CD8 double positive (DP) thymocytes which then rearrange Tcra. Interleukin-7 (IL-7) promotes Bcl2-dependent survival...

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Detalles Bibliográficos
Autores principales: Boudil, Amine, Matei, Irina R., Shih, Han-Yu, Bogdanoski, Goce, Yuan, Julie S., Chang, Stephen G., Montpellier, Bertrand, Kowalski, Paul E., Voisin, Veronique, Bashir, Shaheena, Bader, Gary D., Krangel, Michael S., Guidos, Cynthia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368453/
https://www.ncbi.nlm.nih.gov/pubmed/25729925
http://dx.doi.org/10.1038/ni.3122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368453/
https://www.ncbi.nlm.nih.gov/pubmed/25729925
http://dx.doi.org/10.1038/ni.3122

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