Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage

Affinity maturation, the process in which somatic hypermutation and positive selection generate antibodies with increasing affinity for an antigen, is pivotal in acquired humoral immunity. We have studied the mechanism of affinity gain in a human B-cell lineage in which two main maturation pathways,...

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Detalles Bibliográficos
Autores principales: Xu, Huafeng, Schmidt, Aaron G, O'Donnell, Timothy, Therkelsen, Matthew D, Kepler, Thomas B, Moody, M Anthony, Haynes, Barton F, Liao, Hua-Xin, Harrison, Stephen C, Shaw, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368477/
https://www.ncbi.nlm.nih.gov/pubmed/25524709
http://dx.doi.org/10.1002/prot.24745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368477/
https://www.ncbi.nlm.nih.gov/pubmed/25524709
http://dx.doi.org/10.1002/prot.24745

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