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Excitotoxic Insult Results in a Long-Lasting Activation of CaMKIIα and Mitochondrial Damage in Living Hippocampal Neurons

Over-activation of excitatory NMDA receptors and the resulting Ca(2+) overload is the main cause of neuronal toxicity during stroke. CaMKII becomes misregulated during such events. Biochemical studies show either a dramatic loss of CaMKII activity or its persistent autonomous activation after stroke...

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Detalles Bibliográficos
Autores principales: Otmakhov, Nikolai, Gorbacheva, Elena V., Regmi, Shaurav, Yasuda, Ryohei, Hudmon, Andy, Lisman, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368532/
https://www.ncbi.nlm.nih.gov/pubmed/25793533
http://dx.doi.org/10.1371/journal.pone.0120881